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. 2021 Jun 24;95(14):e00397-21. doi: 10.1128/JVI.00397-21

FIG 2.

FIG 2

Subunit organization of arenavirus GPC. (Left) Schematic drawing of the tripartite GPC protomer. Position 427 in GP2 and position 33 in SSP are labeled and indicated by red and black circles, respectively. Features of GPC include SSP myristoylation (myr), the binuclear SSP-GP2 zinc finger (54, 55) (gray circles), and the N- and C-terminal heptad repeat regions in GP2 (thick lines), diagnostic of class I viral fusion proteins. The drawing is not to scale, and the relative position of SSP is unknown. (Right) Cryo-electron tomography (CryoET) reconstruction of the GPC trimer at a 14-Å resolution (from reference 56). SSP and the transmembrane domain of GP2 are not visible.