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. 2021 May 21;13(6):1748. doi: 10.3390/nu13061748

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Summary of the impact of undernutrition, overnutrition and altered fat distribution on BAT function. BAT activity is decreased in disorders of both reduced and excessive WAT mass compared with normal weight individuals. Fat distribution may also regulate BAT function, for example central (apple-shaped) obesity may impair BAT activity to a greater extent than those with predominant peripheral (pear-shaped) obesity. In addition, lipodystrophy syndromes are associated with reduced BAT function. Brown adipose tissue (BAT), white adipose tissue (WAT), Body mass index (BMI), waist-hip-ratio (WHR).