Table 1.
Common PD-modeling chemicals and their mode of action (in general).
| Substance | Induces Parkinsonism in | Age Dependent Effect | Region (SN) Specificity | NM Affinity | BBB Passage | Mitochondrial Electron-Chain Inhibitor | Forms Quinones | ROS Generator | Induces α-Synuclein/ Lewy Bodies |
|---|---|---|---|---|---|---|---|---|---|
| MPTP/MPP+ |
|
|
|
|
|
|
|
|
species-dependent |
| Paraquat |
|
|
|
|
|
|
|
|
|
| Rotenone |
|
|
|
|
|
|
|
|
|
| 6-OHDA |
|
|
|
|
|
|
|
|
|
= yes, = no.