Table 1.
An overview of potential compounds with a protective effect on I/R injury by inducing the Nrf2 pathway.
| Compound | Related System | References |
|---|---|---|
| Atorvastatin | Cardiovascular system | [85] |
| L-carnitine | Cardiovascular system | [86] |
| DH404 | Cardiovascular system | [87] |
| Plant polyphenols (flavonoids, chalcones, triterpenes, and proanthocyanidins) | Cardiovascular system | [88] |
| Resveratrol | Cardiovascular system | [89,90] |
| Triptolide | Cardiovascular system | [91] |
| Aloin | Cardiovascular system | [92] |
| Allicin | Cardiovascular system | [93] |
| Diallyl sulfide | Cardiovascular system | [93] |
| Luteolin | Cardiovascular system | [94] |
| 14p (a curcumin analog) | Cardiovascular system | [83] |
| Melatonin | Cardiovascular system Urinary system |
[84] [132] |
| Kaempferide | Cardiovascular system | [95] |
| Butin | Cardiovascular system | [96] |
| Crocin | Cardiovascular system | [97] |
| Hyperoside | Cardiovascular system | [98] |
| Soybean isoflavones | Cardiovascular system | [99] |
| CDDO-imidazoline | Hepatobiliary system Urinary system |
[69] [131] |
| Dimethyl fumarate | Hepatobiliary system | [101] |
| Curcumin | Hepatobiliary system | [101] |
| 15-Deoxy-Δ12,14-prostaglandin J2 | Hepatobiliary system | [102] |
| Sulforaphane | Hepatobiliary system | [103] |
| Telluric acid | Hepatobiliary system | [104] |
| 4-IO (an itaconate derivative) | Hepatobiliary system | [71] |
| Perindopril | Hepatobiliary system | [107] |
| Sevoflurane | Hepatobiliary system | [108,109] |
| Fisetin (3,3′,4′,7-tetrahydroxyflavone) | Hepatobiliary system | [110] |
| Gastrodin | Hepatobiliary system | [111] |
| Myricetin | Hepatobiliary system | [112] |
| Interleukin-1 receptor antagonist (IL-1Ra) | Gastrointestinal system | [113] |
| Irisin | Gastrointestinal system | [114] |
| Dimethyl fumarate | Gastrointestinal system | [115] |
| Salvianolic acid A | Gastrointestinal system | [116] |
| Ginsenoside Rb1 | Gastrointestinal system | [117] |
| Higenamine (1-[(4-hydroxyphenyl) methyl]-1,2,3,4-tetrahydroisoquinoline-6,7-diol) | Gastrointestinal system | [118] |
| 11-Keto-β-boswellic acid | Central nervous system | [120] |
| Panax notoginseng saponins | Central nervous system | [121] |
| Z-ligustilide | Central nervous system | [122] |
| RS9 (a novel Nrf2 activator obtained from bardoxolone methyl) | Central nervous system | [123] |
| Nomilin | Central nervous system | [124] |
| Monomethyl fumarate | Central nervous system | [125,126] |
| Resveratrol | Central nervous system | [127] |
| Pterostilbene | Central nervous system | [128] |
| Pinosylvin | Central nervous system | [129] |
| 6 CDDO-ethyl amide (CDDO-EA) | Central nervous system | [130] |
| RTA-408 (a new oleanane triterpenoid compound) | Urinary system | [131] |
| Nordihydroguaiaretic acid | Urinary system | [133] |
CDDO: 2-Cyano-3,12-Dioxooleana-1,9-Dien-28-Oic acid.