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. 2021 May 21;11(6):332. doi: 10.3390/metabo11060332

Figure 4.

Figure 4

The structure of AKR1B10. (a) Tertiary structure complexed with NADP+ and an inhibitor tolrestat (PDB 1ZUA), showing the active site (dotted circle) and residues involved in binding to HSP90α. (b) The orientations of HCCFA (pink) and MK204 (light green) in the active site.