Table 1.

Agents that modulate AKR1B10 expression.

Agent *	Signal Molecule	Cell **	References
Up-regulation
Ethoxyquin	Nrf2	Lung cancer A549, H23	[14]
MG-132, bortezomib	Nrf2	CRC SW-480, HT29	[17]
Doxorubicin	Nrf2	Gastric cancer MKN45	[18]
EGF, insulin	AP-1, ERK	HCC HepG2, Hep3B	[19]
Lipopolysaccharide		Blood mononuclear cells	[20]
BMP, IBMX		Mesenchymal stem cells	[21]
9,10-Phenanthrenequinone	Nrf2, ERK	Lung cancer A549	[22]
Cigarette smoke extract		Airway epithelium	[23]
Carnosic acid, t-BHQ	Nrf2	Astrocytoma U373MG	[15]
5-FU, L-OHP	p53	CRC HT116	[16]
Down-regulation
TPA	c-Jun, ERK	Lung cancer A549	[15]
5-FU, L-OHP		CRC HT29	[16]

Note: * Abbreviations of agents: EGF; epidermal growth factor, BMP, bone morphogenetic protein 2; IBMX, 3-isobutyl-1-methylxanthine; t-BHQ, t-butyl hydroquinone; 5-FU, 5-fluorouracil; L-OHP, oxaliplatin; TPA, 12-O-tetradecanoylphorbol 13-acetate. ** Abbreviations of cancer: CRC, colorectal cancer; HCC, hepatocellular cancer.