Table 4.

Altered ultrasonic communication in Cntnap2 KO mice and Nlgn mutant mice

Mouse model of ASD	USVs features vs. WT mice	References
	Quantitative parameters
Cntnap2 KO
Pups	↓ Number on PND 3, 6 and 9	Peñagarikano et al. (2015)
Adults	↓ Number	Brunner et al. (2015)
Nlgn2 KO
Pups	↓ Number and total calling time on PND 7	Wöhr et al. (2013)
Nlgn4 KO
Pups	No differences in number and duration	Ey et al. (2012)
Adolescents	↓ Number and duration and ↑ latency to first call	Ju et al. (2014)
Adults	↓ Number	Jamain et al. (2008)
	No differences in number and duration	Ey et al. (2012)

ASD: Autism spectrum disorders; KO: knock-out; PND: postnatal day; USVs: ultrasonic vocalizations; WT: wild-type.