Figure 1.

Functional reorganization in ALS based on functional MRI studies.

Motor task studies in ALS have consistently captured increased cerebellar, thalamic and basal ganglia signal and an activation shift from the primary motor cortex to premotor, supplementary motor and ipsilateral motor cortices. Cognitive paradigms have also revealed broadened and aberrant activation patterns and resting state studies captured increased cerebro-cerebellar and default mode network connectivity. ALS: Amyotrophic lateral sclerosis.