Table 2.

Thyroid IRAEs grade in the CTCAE Version 5.0.

Thyroid IRAEs
Term	Grade 1	Grade 2	Grade 3	Grade 4	Grade 5
Hypothyroidism	Asymptomatic; clinical or diagnostic observations only;intervention not indicated	Symptomatic; thyroid replacement indicated; limiting instrumental ADL	Severe symptoms; limiting self-care ADL; hospitalization indicated	Life-threatening consequences; urgent intervention indicated	Death
Hyperthyroidism	Asymptomatic; clinical or diagnostic observations only; intervention not indicated	Symptomatic; thyroid suppression therapy indicated; limiting instrumental ADL	Severe symptoms; limiting self-care ADL; hospitalization indicated	Life-threatening consequences; urgent intervention indicated	Death
Thyroiditis	Asymptomatic; clinical or diagnostic observations only; intervention not indicated	Symptomatic; thyroid suppression therapy indicated; limiting instrumental ADL	Severe symptoms; limiting self-care ADL; hospitalization indicated	Life-threatening consequences; urgent intervention indicated	Death

Hypothyroidism: a disorder characterized by a decrease in the production of thyroid hormone by the thyroid gland.

Hyperthyroidism: a disorder characterized by excessive levels of thyroid hormone in the body. Common causes include an overactive thyroid gland or thyroid hormone overdose.

Thyroiditis: a disorder characterized by transiently obvious hyperthyroidism or subclinical hyperthyroidism and subsequently hypothyroidism.

IRAEs, immune-related adverse events.