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. 2021 Jun 10;11:687647. doi: 10.3389/fcimb.2021.687647

Figure 2.

Figure 2

miRNA profiles of L. braziliensis infected THP-1-macrophages. Volcano plot of differential expression of miRNA in L. (V.) braziliensis promastigote-infected THP-1 macrophages in relation to non-infected cells at 6 h (A) and 24 h (B) post-infection compared to uninfected-macrophages. Each dot represents one miRNA. Red dots indicate the up-regulated miRNAs, and the blue dots represent the down-regulated miRNAs (P < 0.05). Black dotted line corresponds to p = 0.05, log 10. The relative up- and down-regulation of miRNAs, expressed as boundaries of 2 or -2 of Fold Regulation, respectively. P-value was determined based on two-tailed Student’s t test. Significantly expressed miRNAs in different times distributed in four groups (C). Experiments were repeated three times.