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. 2021 Jun 10;11:687647. doi: 10.3389/fcimb.2021.687647

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Copyright © 2021 Souza, Ramos-Sanchez, Muxel, Lagos, Reis, Pereira, Brito, Zampieri, Kaye, Floeter-Winter and Goto

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Predicted interactions between the set of differentially expressed microRNAs in THP-1 cells after 6 and 24 h post infection. The genes on which they are suggested to act in the Leishmaniasis pathway in humans are shown as seen in KEGG. miRNAs were classified into four groups according to their modulation through time: down-regulated in 6 and 24 h (A), up-regulated on 6 h and down-regulated in 24 h (B), down-regulated in 6 h and up-regulated in 24 h (C) and up-regulated in both timepoints (D).