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. 2021 Jun 10;11:687647. doi: 10.3389/fcimb.2021.687647

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Copyright © 2021 Souza, Ramos-Sanchez, Muxel, Lagos, Reis, Pereira, Brito, Zampieri, Kaye, Floeter-Winter and Goto

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Predicted interactions between the set of differentially expressed microRNAs in THP-1 cells after 6 and 24 h post infection with L. braziliensis (A) and in plasma samples from self-healed patients compared to active disease individuals (B) and the biological pathways related to inflammatory response on which they are suggested to act according to MiEAA algorithms. In (B), pathways in red were predictably targeted by in vitro and ex vivo miRNA sets, while the others in blue were evidenced only in miRNAs significantly quantified in plasma.