FIG 1.

miR-181a-2-3p expression was decreased in LPS-induced cell model and CLP mice models. (A) The expression of miR-181a-2-3p in sepsis mice and sham mice was measured by qRT-PCR. RT-PCR assay was used to detect miR-181a-2-3p expression in agomir-181a-2-3p transfection group (B) and antagomir-181a-2-3p transfection group (C). (D and I) The photomicrographs of kidney tissues stained by H&E (200×). (E, F, G, J, K, and L) ELISA was performed to examine the levels of Cr, BUN, NGAL, KIM-1, IL-1β, IL-6, and TNF-α in the serum of each group. (H and M) ELISA was performed to examine the caspase-3 activity. **, P < 0.01; ##, P < 0.01; ^^, P < 0.01.