FIG 9.

Proposed model for the role of vigilin in DNA repair. Upon DNA damage, H2AX is phosphorylated on serine 139 by ATM/ATR kinases. This phosphorylation creates a binding site for various proteins like 53BP1, which affects its downstream target, Rif1. Vigilin in response to DNA damage gets recruited to DNA damage sites in an acetylation-dependent manner and facilitates the recruitment of Rad51/BRCA1 to DNA DSB sites to replace 53BP1 for facilitation of MRN-mediated DNA end resection by RPA loading onto the resulting ssDNA and polymerization by RAD51.