Figure 4.

ALS experiments in control mice (Ctrl) and an Alzheimer disease model (biAT) according to [111]. (A) Illustration of the experimental paradigm. Animals were intubated, and ventilation was controlled. ALS measurements commenced during a period of normoventilation. In order to assess the cerebral vascular response (CVR) to a hypercapnic challenge, animals were hypoventilated. This was followed by a control measurement under normoventilation. Expired CO₂ levels (expCO2) were recorded during the experiments. More details on the protocol can be found in [111,114]. (B) CBF maps and calculation of the CVR based on the baseline CBF and the CBF acquired under hypoventilation. (C) Comparison of CVR in the cortex (Ctx), hippocampus (hipp) and thalamus (thal) of control mice and biAT mice. This figure is based on data presented in [111].