Table 2.
Technique | Frequently Used Sequence | Output Parameters | Contrast Agent | Main Disadvantages |
---|---|---|---|---|
DCE | T1-weighted GE EPI |
IAUGC Ktrans νe kep |
exogenous | AIF Ktrans combined measure |
DSC | T2-weighted SE or T2*-weighted GE EPI |
CBF CBV MTT (Ktrans, νe, kep) |
exogenous | AIF first pass measurement |
ASL | 2D EPI or 3D GRASE |
CBF Bolus arrival time Arterial CBV |
endogenous | low SNR |
IVIM | PGSE EPI | D D* fIVIM |
endogenous | long acquisition time different approaches |
VASO | T1-weighted GE, SE or GRASE EPI |
CBV | exogenous/endogenous | low SNR only measurement of CBV |
iVASO | arterial CBV | exogenous | ||
SSC | T2 -weighted SE or T2*-weighted GE EPI |
relative CBV | exogenous | only measurement of CBV lack of clinically approved contrast agents |
Vessels size imaging | SAGE EPI | VSI | exogenous | first pass measurement or lack of clinically approved contrast agents |
SAGE-based DSC | SAGE EPI | CBF, CBV, MTT Ktrans, νe, kep VSI |
exogenous | AIF first pass measurement |
2D PC MRA | T2-weighted GE | total CBF (CMRO2) |
endogenous | only measurement of global CBF choice of optimal VENC |
QSM | 3D multi-echo GE | OEF (CMRO2) |
endogenous | assumes isotropic magnetic susceptibilities relative quantification |
qBOLD | (multi echo) GE/SE EPI or asymmetric SE EPI |
DBV OEF (CMRO2) |
endogenous | requires additional field map |