Figure 7.

N^CoV2 in different structural states. (a) Schematic illustration of structural and dynamical information on N^CoV2 droplets that would be obtained by the methods described in Figure 6. R_D and R_M show the distance between the NTD and CTD, and the distance between domains of different N^CoV2 molecules, respectively. D_eff denotes the efficient diffusion coefficient of the NTDs/CTDs and/or of the N^CoV2 molecules. In the lower panel, τ, D, and a denote the residence time, the diffusion coefficient, and the amplitude of amino acid side chains and/or backbones, respectively. Hydrogen atoms are shown in red. p and (1-p) show the immobile and mobile fractions of atoms in proteins; (b) N^CoV2 in an isolated state (dimer). Each monomer is shown in sea green and forest green, respectively. The central linker was modelled using the Ranch program [93]; (c) a model of nucleocapsid complex for SARS-CoV [8]. Only CTDs are displayed because NTD positions are unknown. Possible locations of RNA molecules are depicted by brown line. One CTD monomer is shown in marine blue The models in sphere or ribbon representation are depicted using UCSF Chimera [16].