Figure 1.

Effects of HDL-associated or purified apolipoproteins, lipids and enzymes in immune cell activation and function in vitro. Abbreviations: ABCA1—ATP-binding cassette subfamily A member 1; apoA-I—apolipoprotein A-I; apoA-II—apolipoprotein A-II; apoA-IV—apolipoprotein A-IV; apoC-II—apolipoprotein C-II; apoC-III—apolipoprotein C-III; apoE—apolipoprotein E; apoM—apolipoprotein M; CD—cluster of differentiation; CE—cholesteryl ester; FC—free cholesterol; HDL—high-density lipoprotein; ICAM-1—intercellular adhesion molecule 1; IL—interleukin; JAK2—Janus kinase 2; LDL—low-density lipoprotein; LPS—lipopolysaccharide; MCP-1—monocyte chemoattractant protein-1; M-CSF—macrophage colony-stimulating factor; NADPH—nicotinamide adenine dinucleotide phosphate; NLRP3—nod-like receptor family pyrin domain-containing 3; PC—phosphatidylcholine; PGE2—prostaglandin E2; PLPC—1-palmitoyl-2-linoleoyl-phosphatidylcholine; PON—paraoxonase; ROS—reactive oxygen species; S1P—sphingosine-1-phosphate; S1P1—sphingosine-1-phosphate receptor 1; S1P2—sphingosine-1-phosphate receptor 2; S1P3—sphingosine-1-phosphate receptor 3; SAA—serum amyloid A; SLPC—1-stearoyl-2-linoleoyl-phosphatidylcholine; STAT3—signal transducer and activator of transcription 3; TG—triglyceride; Th1—T helper type 1; TLR—Toll-like receptor; TNF-α—tumor necrosis factor α; TRAF-6—TNF receptor-associated factor 6; VCAM-1—vascular cell adhesion molecule 1.