Table 1.
Baseline characteristics of patients treated or not with calcifediol, days of hospitalization, and mortality after 30 days of follow-up.
| Not Treated (n = 458) | Treated (n = 79) | p-Value | |
|---|---|---|---|
| Age | 67 ± 16 | 69 ± 15 | 0.23 |
| Male (%) | 60 | 53 | 0.15 |
| Current smokers (%) e | 5 | 3 | 0.26 |
| CURB-65 ≥ 3 (%) | 21 | 8 | <0.01 |
| ARDS moderate or severe (%) | 25 | 10 | <0.01 |
| Any comorbidity (%) | 68 | 87 | <0.01 |
| Diabetes (%) | 20 | 20 | 0.5 |
| Hypertension (%) | 56 | 58 | 0.4 |
| Cerebrovascular disease (%) | 7 | 6 | 0.53 |
| COPD (%) | 8 | 3 | 0.06 |
| Heart failure (%) | 9 | 5 | 0.16 |
| Chronic kidney disease (%) | 8 | 1 | 0.02 |
| Cancer (%) | 5 | 4 | 0.23 |
| Coronary heart disease (%) | 12 | 9 | 0.29 |
| Dementia (%) | 8 | 8 | 0.60 |
| ACEi/ARBs (%) | 48 | 39 | 0.13 |
| SaO2 at admission | 93 ± 6 | 95 ± 4 | 0.03 |
| CRP a | 130 ± 100 | 100 ± 80 | 0.04 |
| Lymphocytes | 1150 ± 820 | 970 ± 480 | 0.05 |
| Neutrophil-to-lymphocyte ratio | 7 ± 7 | 6 ± 5 | 0.66 |
| LDH b | 340 ± 170 | 330 ± 150 | 0.50 |
| D-dimer c | 2500 ± 7200 | 1900 ± 5000 | 0.48 |
| Ferritin d | 950 ± 1210 | 650 ± 680 | 0.07 |
| Blood urea nitrogen | 22 ± 19 | 16 ± 15 | 0.01 |
| Systemic corticosteroids (%) | 45 | 38 | 0.15 |
| Orotracheal intubation, n (%) | 26 (6) | 3 (4) | 0.36 |
| Mortality, n (%) | 90 (20) | 4 (5) | <0.001 |
a. CRP n = 346; b. LDH n = 480; c. D-dimer n = 480; d. Ferritin n = 296; e. Smoking status n = 508. Results are mean ± SD or % as indicated. p-values were calculated with Fisher’s exact test for categorical variables (Exact Sig. 1-sided) and the Student’s t-test or Kruskal–Wallis test for continuous ones. Abbreviations: ACEi/ARBs, angiotensin-converting enzyme inhibitor or angiotensin II receptor antagonists; ARDS, acute respiratory distress syndrome; COPD, chronic obstructive pulmonary disease; CRP, c-reactive protein; CURB-65, CURB-65 score for pneumonia severity; LDH, lactate dehydrogenase; SaO2, arterial oxygen saturation.