Table 2.
Patient | Gender | Age | HSCT Type | Conditioning Regimen | Underlying Disease | Baseline 2D-SWE (m/S) | Baseline 2D-SWE (kPa) | Baseline PV Velocity (cm/S) | Clinical SOS/VOD Diagnosis † | Serum Bilirubin >2 mg/dL at Diagnosis | SWE at SOS/VOD Diagnosis (m/S) | SWE at SOS/VOD Diagnosis (kPa) | Max. Increase in SWE (m/S; kPa) | Max. SWE (m/S; kPa) | Ascites in US | Decreased/Reversed PV Flow | Gallbladder Wall Thickening | Date of US/SWE | SOS/VOD Severity † | Max. Bilirubin (mg/dL) | SOS/VOD Therapy | Outcome | SWD ((m/S)/kHz); (day) |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | male | 36 | allogenic (MMUD) | 4 × 3.2 mg/kg busulfan, 2 × 60 mg/kg cyclophosphamide | AML | 1.42 | 5.9 | 29 | +18 | 3.26 | 4.17 | 58.8 | 2.75; 52.9 | 4.17; 58.8 | yes ‡ | yes | yes | +18 | severe | 34.71 | DEF, diuretics | Death (+110) | 16.7 (+20) |
2 | female | 64 | allogenic (MUD) | treosulfan, fludarabine, thiothepa | MM | 1.26 | 4.7 | 29 | +18 | 5.62 | 1.71 | 8.9 | 0.52; 5 | 1.78; 9.8 | no | no | no | +19 | severe | 20.76 | DEF, diuretics | death (+63) | 17.2 (+54) |
3 | male | 45 | allogenic (MUD) | 4 × 3.2 mg/kg busulfan, 2 × 60 mg/kg cyclophosphamide | CML | 1.20 | 4.2 | 16 | +21 | 4.46 | 2.11 | 13.9 | 2.52; 41.3 | 3.72; 45.5 | yes ‡ | yes | yes | +47 | severe | 35.83 | DEF, diuretics | death (+78) | 20.9 (+47) |
Abbreviations: MUD, matched unrelated donor; MMUD, mismatch unrelated donor; AML, acute myeloid leukemia; MM, multiple myeloma; PV, portal vein; † according to Mohty et al. 2016 [7]; US, ultrasound; DEF, defibrotide; SWE, shear wave elastography; SWD, shear wave dispersion. ‡ Small amounts of ascites, no detection of ascites in the area of 2D-SWE measurement.