Figure 1.

The monoamine hypothesis: main brain structures, neurotransmitters, biologically active substances, and interactions. BDNF—brain-derived neurotrophic factor; BNST—bed nuclei stria terminalis; CRF—corticotropin-releasing factor; DA—dopamine; DPFC—dorsal prefrontal cortex; Glu—glutamine; GABA—gamma-aminobutyric acid; HiN—histamine; Hipp—hippocampus; HT—hypothalamus; 5-HT—serotonin; LC—locus ceruleus; NA—noradrenaline; NAc—nucleus accumbens; Oxn—orexin; SCN—suprachiasmatic nucleus; TMN—tuberomammilar nucleus; RN—raphe nucleus; PVN—paraventricular nucleus; VOPFC—ventral and orbital prefrontal cortex; VTA—ventral tegmental area; -> (arrow): activating effect; -<> (rhombus): a black rhombus—inhibitory effect; thick line—effect is increased; thin line—effect is decreased; medium thickness line—effect is not changed, or alterations of the effect are unknown; red line—noradrenaline effect; blue line—serotonin effect; black line—various neurotransmitters or neuropeptides.