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Mathematical model predictions of plasma cortisol levels assuming constant absorption (kα) and secretion (k) rates. The model fits the data during the first three hours (a), but for the estimated (k, kα) values, it significantly deviates from the observed plasma cortisol values past the first three hours (b). Plasma cortisol measurements belong to Subject 1 from the Pulses study (see Materials and Methods). CORT: cortisol.
