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. 2021 May 21;13(6):769. doi: 10.3390/pharmaceutics13060769

Figure 3.

Figure 3

Simulation of plasma cortisol changes in different healthy subjects with pharmacologically suppressed cortisol biosynthesis with dexamethasone (see Materials and Methods) after the subcutaneous infusion of varying doses of hydrocortisone. The simulations were produced by the revised model (see Materials and Methods), which assumes discretely varying absorption and secretion rates of cortisol. (a) female subject, BMI: 20.4, pulse time: 10:00 a.m., pulse volume (D): 30 μL (0.3 mg); (b) male subject, BMI: 30, pulse time: 10:00 a.m., pulse volume (D): 150 μL (1.5 mg); (c) male subject, BMI: 22.5, pulse time: 10:30 a.m., pulse volume (D): 200 μL (2 mg); (d) male subject, BMI: 21.2, pulse time: 09:50 a.m., pulse volume (D): 350 μL (3.5 mg), (e) male subject, BMI: 23.3, pulse time: 10:10 a.m., pulse volume (D): 350 μL (3.5 mg); (f) female subject, BMI: 23.4, pulse time: 09:50 a.m., pulse volume (D): 400 μL (4 mg); BMI: body-mass index, CORT: cortisol, D: dose.