Table 1.
Biomodelling Parameters.
| Parameter | Description | Means of Estimation | Units |
|---|---|---|---|
| C(t) | Plasma cortisol concentration as a function of time. | Predicted by the model | nmol/L |
| Sc(t) | Subcutaneous cortisol concentration as a function of time. | Predicted by the model | mg |
| Di | Hydrocortisone dosage | Known from the experiment | mg |
| kα(t) | Cortisol absorption rate in subcutaneous tissue. Real positive number. | Initial value fitted to data | 1/min |
| k(t) | Plasma cortisol clearance rate. Real positive number. | Initial value fitted to data | 1/min |
| t | Time | Self-explanatory | min |
| σ | Initial cortisol levels in the subjects’ bloodstream (C(0)) | Known from the experiment | nmol/L |
| h | Unit conversion factor for concentration from mg to nmol/L in plasma. Real number, constant, h = 106/(362.42 × ℓ) | Self-explanatory | nmol/mg |
| ℓ | Plasma volume of a typical subject. | Estimated from the literature. | L |