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. 2021 Jun 24;8(12):2101964. doi: 10.1002/advs.202101964

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© 2021 The Authors. Advanced Science published by Wiley‐VCH GmbH

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Figure S3 — USP38 is dispensable for the TLR‐stimulated signaling cascade. (A‐B) Immunoblot analysis of phosphorylated (p‐) and total proteins in whole‐cell lysates of WT and Usp38‐KO BMDMs (A) and BMDCs (B) that were stimulated with LPS for the indicated time points. (C) Immunoblot analysis of phosphorylated (p‐) and total protein in whole‐cell lysates of USP38‐inducible THP1 cells with or without DOX that were stimulated with LPS for the indicated time points. (D) Immunoblot analysis of phosphorylated p65 in PBMCs silenced with control siRNA (siCtrl) or USP38‐specific siRNA (siUSP38) under LPS treatment for the indicated time points. (E) Immunoblot analysis of USP38 in the chromatin‐bound and unbound components of WT and Usp38‐KO BMDMs under LPS treatment for the indicated time points. Data are representative of 3 independent biological experiments.