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. 2021 Mar 16;8(12):2004586. doi: 10.1002/advs.202004586

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© 2021 The Authors. Advanced Science published by Wiley‐VCH GmbH

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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A) The macropinocytosis pathway of MSN‐ALN‐Gd nanovehicle; B) a diagram of nontargeted and targeted carriers binding to bone chips; C) the relative HA binding efficiency. Reproduced with permission.^[ ¹³¹ ^] Copyright 2017, Royal Society of Chemistry. D) Au@MSNs combine ZOL and PTT for treating breast cancer bone metastasis. Reproduced with permission.^[ ¹³³ ^] Copyright 2019, American Chemical Society. E) Scheme of diagnosis and treatment of bone‐targeting PUCZP; F) theranostic effects of PUCZP against early bone metastasis. Reproduced with permission.^[ ¹³⁷ ^] Copyright 2017, American Chemical Society.