Table 1:
Patient | Age at CAR T/ Gender |
Diagnosis | Donor Type | Graft source |
Conditioning regimen with alloHCT |
GVHD prophylaxis/ GVHD at CAR T |
Interval/ lines of therapy between alloHCT and CAR T (days) |
Donor chimerism at the time of mononuclear apheresis |
CRS/ Neurotoxicity |
Response at 1 month |
B cell recovery |
Status at last follow up |
---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | 38/ M | T cell rich DLBCL | 10/10 MUD | Peripheral blood | Flu, Cy, Thio, 400cGy TBI | Tacrolimus, Methotrexate/ none | 1,914/ one | T cell chimerism 100% donor | Grade 2/ Grade 2 | PR | Not achieved until last follow up | Dead (106 days post CAR T) from disease |
2 | 55/ M | Non-GCB DLBCL | MMRD (haploidentical from cousin) | Bone marrow | Flu Mel, Thiotepa | Post-transplant Cy, Tacrolimus, Mycophenolate/ chronic GVHD stable on ibrutinib | 269/ two | Whole blood 100% donor (T cell subset chimerism not available) | None/ none | CR | B cell recovery at 9 months | Alive with CR (270 days post CAR T) |
3 | 56/ M | Non-GCB DLBCL | 10/10 MUD | Peripheral blood | Thio, Bu, Cy, Rituximab | Tacrolimus, Alemtuzumab/ none | 291/ three | T cell chimerism 18% donor | None/ none | POD | Not achieved until last follow up | Dead (77 days post CAR T) from disease |
4 | 66/ F | Double hit DLBCL | 9/10 MMUD | Peripheral blood | Flu, Mel | Tacrolimus, Methotrexate/ none | 694/ none | Bone marrow (unsorted) 100% donor | Grade 2/ none | CR | Not available | Alive with CR (112 days post CAR T) |
All patients received Flu/ Cy lymphodepletion and axicabtagene ciloleucel (2 x 108 cells)
alloHCT, Allogeneic hematopoietic cell transplantation; Bu, Busulfan; CAR-T, Chimeric Antigen Receptor T cell therapy; CR, complete response; CRS, Cytokine release syndrome; Cy, Cyclophosphamide; DLBCL, Diffuse large B cell lymphoma; F, Female; Flu, Fludarabine; GCB, Germinal Center B cell like; GVHD, Graft versus host disease; M, Male; Mel, Melphalan; MMRD, Mismatched related donor; MMUD, Mismatched unrelated donor; MUD, Matched unrelated donor; POD, Progression of disease; PR, Partial response; TBI, Total Body Irradiation; Thio, thiotepa