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. Author manuscript; available in PMC: 2021 Jun 24.
Published in final edited form as: Leukemia. 2019 May 21;33(10):2540–2544. doi: 10.1038/s41375-019-0476-y

Table 1:

Patient and Treatment Characteristics*

Patient Age at
CAR T/
Gender
Diagnosis Donor Type Graft
source
Conditioning
regimen with
alloHCT
GVHD
prophylaxis/
GVHD at CAR T
Interval/
lines of
therapy
between
alloHCT
and CAR T
(days)
Donor
chimerism at
the time of
mononuclear
apheresis
CRS/
Neurotoxicity
Response
at 1
month
B cell
recovery
Status at
last follow
up
1 38/ M T cell rich DLBCL 10/10 MUD Peripheral blood Flu, Cy, Thio, 400cGy TBI Tacrolimus, Methotrexate/ none 1,914/ one T cell chimerism 100% donor Grade 2/ Grade 2 PR Not achieved until last follow up Dead (106 days post CAR T) from disease
2 55/ M Non-GCB DLBCL MMRD (haploidentical from cousin) Bone marrow Flu Mel, Thiotepa Post-transplant Cy, Tacrolimus, Mycophenolate/ chronic GVHD stable on ibrutinib 269/ two Whole blood 100% donor (T cell subset chimerism not available) None/ none CR B cell recovery at 9 months Alive with CR (270 days post CAR T)
3 56/ M Non-GCB DLBCL 10/10 MUD Peripheral blood Thio, Bu, Cy, Rituximab Tacrolimus, Alemtuzumab/ none 291/ three T cell chimerism 18% donor None/ none POD Not achieved until last follow up Dead (77 days post CAR T) from disease
4 66/ F Double hit DLBCL 9/10 MMUD Peripheral blood Flu, Mel Tacrolimus, Methotrexate/ none 694/ none Bone marrow (unsorted) 100% donor Grade 2/ none CR Not available Alive with CR (112 days post CAR T)
*

All patients received Flu/ Cy lymphodepletion and axicabtagene ciloleucel (2 x 108 cells)

alloHCT, Allogeneic hematopoietic cell transplantation; Bu, Busulfan; CAR-T, Chimeric Antigen Receptor T cell therapy; CR, complete response; CRS, Cytokine release syndrome; Cy, Cyclophosphamide; DLBCL, Diffuse large B cell lymphoma; F, Female; Flu, Fludarabine; GCB, Germinal Center B cell like; GVHD, Graft versus host disease; M, Male; Mel, Melphalan; MMRD, Mismatched related donor; MMUD, Mismatched unrelated donor; MUD, Matched unrelated donor; POD, Progression of disease; PR, Partial response; TBI, Total Body Irradiation; Thio, thiotepa