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. 2021 Jun 10;8:679934. doi: 10.3389/fcvm.2021.679934

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Copyright © 2021 de Breet, Zwaveling, Vries, van Oerle, Henskens, van't Hof, van der Meijden, Veenstra, ten Cate and Olie.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Thrombin generation (TG) in PPP patients with (n = 15) and without (n = 78) clinically relevant bleeding (N = 93) during follow-up (bleedings recorded at T2 and T3). (A) ETP, (B) Peak, (C) Velocity index, (D) Lag time, and (E) Time to peak. Significant lower ETP levels (p ≤ 0.001), peak height (p = 0.004), and velocity index (p = 0.016) in patients with clinically relevant bleeding during follow-up. Significant longer time to peak (p = 0.007) and lag time (p = 0.036) in patients with clinically relevant bleeding. Means are indicated by lines. *p < 0.05. ETP, Endogenous Thrombin Potential; PPP, Platelet Poor Plasma; N, number of patients.