Table 3.
Coagulation factors as determinants of thrombin generation—multiple regression analysis.
| ETP | Peak | Velocity index | Lag time | Time to peak | |
|---|---|---|---|---|---|
| Beta (95% CI) | |||||
| (Adjusted R2) | 0.104 | 0.255 | 0.273 | 0.265 | 0.161 |
| Fibrinogen | 49.344 (−38.385–137.073) | 5.050 (−10.132–20.233) | 2.339 (−2.700–7.379) | 0.788* (0.270–1.370) | 0.688* (0.119–0.1258) |
| vWF activity | −0.174 (−1.930–1.582) | −0.017 (−0.320–0.287) | 0.006 (−0.095–0.107) | 0.005 (−0.005–0.015) | 0.004 (−0.008–0.015) |
| Factor II activity | 8.675* (1.336–16.014) | 0.666 (−0.604–1.936) | 0.099 (−0.323–0.520) | −0.025 (−0.068–0.019) | −0.007 (−0.055–0.040) |
| Factor V activity | −2.220 (−5.574–1.134) | −0.663* (−1.244– −0.083) | −0.181 (−0.374–0.011) | 0.018 (−0.002–0.038) | 0.021 (0.000–0.043) |
| Factor VII activity | −0.977 (−4.454–2.500) | 0.031 (−0.571–0.632) | 0.030 (−0.169–0.230) | −0.008 (−0.029–0.120) | −0.011 (−0.033–0.012) |
| Factor VIII activity | 2.128* (0.045–4.210) | 0.516* (0.156–0.877) | 0.171* (0.052–0.291) | −0.003 (−0.015–0.009) | −0.008 (−0.022–0.005) |
| Factor IX activity | −1.120 (−5.125–2.885) | 0.012 (−0.681–0.705) | 0.013 (−0.218–0.243) | −0.003 (−0.027–0.020) | −0.002 (−0.028–0.024) |
| Factor X activity | −1.629 (−6.824–3.567) | 0.051 (−0.849–0.950) | 0.115 (−0.184–0.413) | 0.026 (−0.005–0.057) | 0.011 (−0.023–0.045) |
| Factor XI activity | −1.665 (−3.876–0.546) | −0.219 (−0.601–0.164) | −0.059 (−0.186–0.068) | 0.009 (−0.004–0.022) | 0.008 (−0.006–0.022) |
| Factor XII activity | 1.149 (−1.631–3.928) | 0.083 (−0.398–0.564) | −0.030 (−0.190–0.129) | −0.007 (−0.024–0.009) | −0.005 (−0.023–0.013) |
*
Indicates a p < 0.05, considered as significant.
CI, confidence interval; ETP, endogenous thrombin potential; vWF, von willebrand factor.