Table 2.
Most abundant viruses at species level in transient and mature human milk samples based on delivery type, prematurity, and birth weight for gestational age.
| Transient Human Milk (7–15 Days) | Mature Human Milk (45–90 Days) | ||||||
|---|---|---|---|---|---|---|---|
| Group | Species | n | % | Group | Species | n | % |
| NS-T (n = 432) |
Picornavirinae | 240 | 55.5 | NS-T (n = 482) |
Siphoviridae_n__uc | 170 | 35.2 |
| Cp1virus__uc | 57 | 13.2 | Siphoviridae_n_n__uc | 69 | 14.3 | ||
| Staphylococcus phage Andhra | 27 | 6.25 | Enterococcus phage EFC-1 | 30 | 6.2 | ||
| Staphylococcus phage St 134 | 23 | 5.32 | Picovirinae__uc | 29 | 6.0 | ||
| Halomonas phage phiHAP-1 | 14 | 3.24 | Human betaherpesvirus 5 | 25 | 5.2 | ||
| Streptococcus virus Cp1 | 13 | 3.0 | Clostridium phage vB_CpeS-CP51 | 17 | 3.5 | ||
| Vibrio phage VP882 | 9 | 2.0 | Brochothrix phage NF5 | 16 | 3.3 | ||
| Human betaherpesvirus 5 | 9 | 2.0 | Sextaecvirus__uc | 14 | 2.9 | ||
| CS-T (n = 397) |
Sep1virus__uc | 144 | 36.2 | CS-T (n = 243) |
Human betaherpesvirus 5 | 73 | 30.0 |
| Picovirinae__uc | 51 | 12.8 | Sep1virus__uc | 67 | 27.5 | ||
| Siphoviridae_n_n__uc32 | 32 | 8.1 | Siphoviridae_n_n__uc | 19 | 7.8 | ||
| Streptococcus phage IPP62 | 25 | 6.3 | Myoviridae__uc | 8 | 3.2 | ||
| Staphylococcus virus SEP1 | 20 | 5.0 | Staphylococcus virus SEP1 | 8 | 3.2 | ||
| Siphoviridae_n__uc | 19 | 4.8 | Podoviridae__uc | 7 | 2.9 | ||
| Myoviridae__uc | 13 | 3.2 | Staphylococcus virus IPLAC1C | 5 | 2.0 | ||
| Staphylococcus virus IPLAC1C | 11 | 2.7 | Picovirinae__uc | 5 | 2.0 | ||
| PT (n = 462) |
Picovirinae__uc | 208 | 45.0 | PT (n = 404) |
Human betaherpesvirus 5 | 85 | 21.0 |
| Sep1virus__uc | 60 | 12.9 | Siphoviridae_n__uc | 57 | 14.1 | ||
| Staphylococcus phage St 134 | 34 | 7.35 | Siphoviridae_n_n__uc | 41 | 10.1 | ||
| Human betaherpesvirus 5 | 26 | 5.6 | Picovirinae__uc | 19 | 4.7 | ||
| Siphoviridae_n__uc | 24 | 5.2 | Lactobacillus phage iLp1308 17 | 17 | 4.2 | ||
| Podoviridae__uc | 13 | 2.8 | Staphylococcus virus Sextaec | 15 | 3.7 | ||
| Siphoviridae_n_n__uc | 13 | 2.8 | Listeria phage B054 | 12 | 2.9 | ||
| Pseudomonas phage phiAH14b | 10 | 2.1 | Herpesviridae__uc | 12 | 2.9 | ||
| SGA (n = 176) |
Roseolovirus__uc | 64 | 36.3 | SGA (n = 481) |
Human betaherpesvirus 5 | 133 | 27.6 |
| Acinetobacter virus 133 | 35 | 19.8 | Siphoviridae_n_n__uc | 98 | 20.3 | ||
| Siphoviridae_n__uc | 18 | 10.2 | Roseolovirus__uc | 84 | 17.4 | ||
| Siphoviridae_n_n__uc | 10 | 5.7 | Siphoviridae_n__uc | 76 | 15.8 | ||
| Human betaherpesvirus 6A | 8 | 4.5 | Streptococcus phage YMC-2011 | 15 | 3.1 | ||
| Human betaherpesvirus 5 | 5 | 2.8 | Streptococcus phage 7201 | 10 | 2.0 | ||
| Serratia phage BF | 4 | 2.3 | Human betaherpesvirus 6A | 10 | 2.0 | ||
| LGA (n = 60) |
Siphoviridae_n_n__uc | 16 | 26.6 | LGA (n = 158) |
Siphoviridae_n_n__uc | 71 | 44.9 |
| Lactobacillus phage phi jlb1 | 7 | 11.6 | Siphoviridae_n__uc | 18 | 11.3 | ||
| Human betaherpesvirus 5 | 7 | 11.6 | Sep1virus__uc | 10 | 6.3 | ||
| Lactobacillus phage phiPYB5 | 5 | 8.3 | Human betaherpesvirus 5 | 8 | 5.0 | ||
| Lactobacillus phage KC5a | 4 | 6.6 | Streptococcus phage YMC-2011 | 5 | 3.1 | ||
NS-T: normal spontaneous vaginal delivery-term; CS-T: cesarean delivery-term; PT: premature; SGA: small for gestational age; LGA: large for gestational age (LGA); n: reads.