Figure 3.

Effect of GABAA-R vs. GABAB-R agonists in MHV-1-infected mice. Mice were inoculated with MHV-1 (5 × 10³ PFU) and immediately given plain drinking water, or water containing GABA (2 mg/mL), homotaurine or baclofen. The average daily water consumption per mouse in each group is shown in Supplemental Figure S8: (A) Daily changes in mean % ± SEM of body weights post-infection (% of day 0), *** p < 0.001 vs. control, computed by a RM ANOVA model; (B) Daily scores for the severity of their illness. The data shown are the mean illness scores ± SEM for each group. p values are indicated for each treatment vs. the control as calculated by the Kruskal–Wallis test. * p < 0.05, *** p < 0.001; (C) Daily percent of surviving mice in each group. Indicated p values vs. the control were calculated by the log-rank test; (D) Lung coefficient indexes. The lungs were harvested and weighed when an animal became moribund or at 14 days post-infection. The data shown are the mean lung coefficient index ± SEM for each group. * p < 0.05, *** p < 0.001 vs. the control water treated group by Student’s t-test. For all studies, n = 10 mice/group from two separate experiments.