Table 1.

Physiological measurements of mice utilized in this study. The heart weight, body weight, and non-fasting blood glucose levels were measured before isolation of cardiac fibroblasts. The data presented consist of the mean ± SEM, and n value indicates number of mice used where 2–3 mouse hearts were used per cardiac fibroblast isolation. Statistical analysis consisted of one-way ANOVA followed by a Dunnett’s post hoc compared to non-diabetic mice (* p < 0.05 and **** p < 0.0001).

	Heart Weight	Blood Glucose (mg/dL)
	Body Weight
Non-Diabetic (n = 25)	0.0038 ± 7.9128 × 10−5	190.6 ± 4.323
Diabetic (n = 18)	0.0017 ± 6.269 × 10−5 ****	546.1 ± 24.07 ****
Rap1a KO (n = 22)	0.0041 ± 11.18 × 10−5 *	180.0 ± 8.334
Non-Diabetic RKO (n = 20)	0.0037 ± 6.256 × 10−5	204.2 ± 4.454
Diabetic RKO (n = 13)	0.0022 ± 3.534 × 10−5 ****	456.4 ± 29.24 ****