Table 4.
Comparison of lymphocyte subsets between non-ICU and ICU patients with COVID-19.
| Lymphocyte Subsets | Normal Ranges /µL |
All Patients (n = 82) |
Non-ICU COVID-19 Patients (n = 51) |
ICU COVID-19 Patients (n = 31) |
p |
|---|---|---|---|---|---|
| T cells (CD3+)/µL | 617–2383 | 503 (340–798) | 620 (450–1010) | 340 (250–600) | <0.001 |
| Helper T cells (CD3+CD4+)/µL | 424–1513 | 340 (210–536) | 374 (279–588) | 245 (150–395) | 0.002 |
| Suppressor T cells (CD3+CD8+)/µL | 101–955 | 152 (95–270) | 191 (116–360) | 100 (68–172) | <0.001 |
| Naïve helper T cells (CD3+CD4+CD45RA+)/µL | 84–761 | 160 (98–275) | 163 (111–367) | 125 (64–223) | 0.044 |
| Naïve suppressor T cells (CD3+CD8+CD45RA+)/µL | 100–400 | 99 (68–195) | 128 (86–238) | 70 (50–110) | <0.001 |
| Activated T cells (CD3+HLA-DR+)/µL | 30–200 | 34 (21–60) | 30 (18–43) | 44 (28–100) | 0.007 |
| Activated suppressor T cells (CD3+CD8+HLA-DR+)/µL | 30–180 | 17 (7–33) | 13 (7–27) | 22 (7–55) | 0.18 |
| Regulatory T cells (CD3+CD4+CD25+CD127low+)/µL | 30–120 | 21 (16–36) | 26 (18–44) | 17 (12–25) | 0.001 |
| Naïve regulatory T cells (CD45RA+CD3+CD4+CD25+CD127low+)/µL |
9–36 | 3 (1–9) | 4 (2–10) | 2 (1–4) | <0.001 |
| Induced regulatory T cells (CD45RO+CD3+CD4+CD25+CD127low+)/µL |
21–84 | 18 (12–27) | 22 (14–33) | 14 (10–20) | 0.007 |
| TCRα/β/µL | 573–2216 | 488 (320–780) | 597 (412–940) | 330 (250–598) | <0.001 |
| TCRγ/δ/µL | 30–119 | 11 (5–44) | 23 (8–60) | 4 (2–13) | <0.001 |
| CD25+CD3+/µL | 7–94 | 64 (40–95) | 75 (56–119) | 40 (26–71) | 0.001 |
| B cells (CD19+)/µL | 31–527 | 129 (68–198) | 128 (67–220) | 130 (70–185) | 0.85 |
| B cells (CD19+CD20+)/µL | 66–528 | 265 (167–375) | 300 (197–423) | 190 (134–310) | 0.001 |
| NK cells (CD16+CD56+)/µL | 110–678 | 88 (47–192) | 145 (81–217) | 40 (17–77) | <0.001 |