Table 5.
Comparison of lymphocyte subsets between patients with COVID-19 who recovered and died.
| Lymphocyte Subsets | Normal Ranges /µL |
All Patients (n = 82) |
Recovered COVID-19 Patients (n = 54) |
Died COVID-19 Patients (n = 28) |
p |
|---|---|---|---|---|---|
| T cells (CD3+)/µL | 617–2383 | 503 (340–798) | 600 (450–990) | 335 (268–535) | <0.001 |
| Helper T cells (CD3+CD4+)/µL | 424–1513 | 340 (210–536) | 390 (279–584) | 225 (154–364) | 0.001 |
| Suppressor T cells (CD3+CD8+)/µL | 101–955 | 152 (95–270) | 186 (116–352) | 103 (70–170) | 0.001 |
| Naïve helper T cells (CD3+CD4+CD45RA+)/µL | 84–761 | 160 (98–275) | 167 (118–280) | 120 (63–204) | 0.016 |
| Naïve suppressor T cells (CD3+CD8+CD45RA+)/µL | 100–400 | 99 (68–195) | 126 (78–230) | 79 (53–105) | 0.002 |
| Activated T cells (CD3+HLA-DR+)/µL | 30–200 | 34 (21–60) | 33 (20–54) | 35 (23–71) | 0.4 |
| Activated suppressor T cells (CD3+CD8+HLA-DR+)/µL | 30–180 | 17 (7–33) | 17 (8–30) | 13 (6–41) | 0.81 |
| Regulatory T cells(CD3+CD4+CD25+CD127low+)/µL | 30–120 | 21 (16–36) | 26 (19–43) | 17 (12–21) | <0.001 |
| Naïve regulatory T cells (CD45RA+CD3+CD4+CD25+CD127low+)/µL |
9–36 | 3 (1–9) | 4 (2–10) | 2 (1–3) | <0.001 |
| Induced regulatory T cells (CD45RO+CD3+CD4+CD25+CD127low+)/µL |
21–84 | 18 (12–27) | 21 (14–32) | 14 (10–20) | 0.003 |
| TCRα/β/µL | 573–2216 | 488 (320–780) | 588 (412–940) | 325 (255–532) | <0.001 |
| TCRγ/δ/µL | 30–119 | 11 (5–44) | 20 (8–53) | 5 (2–14) | <0.001 |
| CD25+CD3+/µL | 7–94 | 64 (40–95) | 75 (60–116) | 40 (27–57) | <0.001 |
| B cells (CD19+)/µL | 31–527 | 129 (68–198) | 130 (70–235) | 101 (67–155) | 0.24 |
| B cells (CD19+CD20+)/µL | 66–528 | 265 (167–375) | 300 (220–420) | 165 (125–285) | <0.001 |
| NK cells (CD16+CD56+)/µL | 110–678 | 88 (47–192) | 135 (78–204) | 42 (18–66) | <0.001 |