Kinase Abbreviations
AMPK	AMP-activated protein kinase
CDK1/2/5/6/9	cyclin-dependent kinases
Chk1,	checkpoint kinase 1
CK2	casein kinase 2
DRAK2	death-associated protein-related apoptotic kinase 2
DYRK	dual-specificity tyrosine-phosphorylated and regulated kinase
EGFR	epidermal growth factor receptor tyrosine kinase
ERK	extracellular signal-regulated kinase
FLT3	FMS-related receptor tyrosine kinase 3
GSK-3α/β	glycogen synthase kinase 3
IGF1R	receptor of insulin-like growth factor type 1
IRAK4	interleukin-1 receptor-associated kinase 4
JAK1/2/3	Janus kinases 1/2/3, tyrosine kinases
JNK	c-Jun N-terminal kinase
Lck	lymphocyte-specific protein tyrosine kinase
Lyn	non-receptor tyrosine-protein kinase
PhK	serine/threonine-specific phosphorylase kinase
PI3K	phosphatidylinositol 3-kinase
PKR	RNA-dependent protein kinase R
RSK2	ribosomal S6 kinase 2
SGK	serine/threonine-protein kinase Sgk1 (serum and glucocorticoid-regulated kinase 1)
VEGFR1/2	vascular endothelial growth factor receptor tyrosine kinase
Other Abbreviations
ALP	alkaline phosphatase
AP-1	activator protein 1
ASIC	acid-sensing ion channel
ATF-2	activating transcription factor 2
CAIA	collagen-antibody-induced arthritis
CCI	chronic constriction injury
CCL	chemokine ligand
CCR5	chemokine receptor 5
CFA	complete Freund’s adjuvant
CIA	collagen-induced arthritis
COX-2	cyclooxygenase 2
CysLT	cysteinyl leukotriene
DTH	delayed-type hypersensitivity
eNOS	endothelial NO synthase
FLS	fibroblast-like synoviocytes
GluR6	glutamate receptor 6
GM-CSF	granulocyte-macrophage colony-stimulating factor
HIV	human immunodeficiency virus
HNE	human neutrophil elastase
HO-1	heme oxygenase 1
Hsp90	heat shock protein 90
HUVECs	human umbilical vein endothelial cells
IFN	interferon
IL	interleukin
iNOS	inducible nitric oxide synthase
IP-10	interferon γ-induced protein 10
LO	lipoxygenase
LPS	lipopolysaccharide
LTB4	leukotriene B4
MAPK	mitogen-activated protein kinase
MCA	middle cerebral artery
MCP	monocyte chemoattractant protein
MMECs	mouse mammary epithelial cells
MMP	matrix metalloproteinase
MPO	myeloperoxidase
NF-κB	nuclear factor κB
NO	nitric oxide
NSAIDs	nonsteroidal anti-inflammatory drugs
OCN	osteocalcin
PBMCs	peripheral blood mononuclear cells
PDE	phosphodiesterase
PGE2	prostaglandin E2
Pr3	proteinase 3
PTGS-2	prostaglandin endoperoxide synthase 2
RANKL	receptor activator of NF-κB ligand
RANTES	regulated on activation, normal T cell expressed and secreted
ROS	reactive oxygen species
Runx2	runt-related transcription factor 2
S.c.	subcutaneous
SOD	superoxide dismutase
STAT	signal transducer and activator of transcription
TGF-β	transforming growth factor β
TLR	Toll-like receptor
TNF	tumor necrosis factor
TRPA1	transient receptor potential ankyrin 1
TRPV1	transient receptor potential vanilloid 1
VDAC,	voltage-dependent anion channel
VEGFA	vascular endothelial growth factor A
VSMCs	vascular smooth muscle cells
Chemical Names
Compound 1 (E231)	indirubin-3′-oxime
Compound 2	indirubin-3′-acetoxime
Compound 3 (E804)	indirubin-3′-oxime 2,3-dihydroxypropyl ether
Compound 4 (E738)	5-methoxyindirubin-3′-oxime 1,2-dihydroxyethyl ether
Compound 5	5′,6′-difluoro-5-methoxy-indirubin-3′-oxime 2-hydroxyethyl ether
Compound 6 (LDD970)	5-[(1-morpholino)carbonyl]indirubin-3′-oxime
Compound 7 (AGM130)	5-nitro-5′-hydroxyindirubin-3′-oxime
Compound 8	5-(pentanamido)indirubin-3′-oxime
Compound 9 (LDD1937)	5-(methoxycarbonyl)indirubin-3′-oxime 2-(piperazin-1-yl)ethyl ether dihydrochloride
Compound 10	5-iodoindirubin-3′-oxime
Compound 11	6-bromoindirubin-3′-oxime
Compound 12	6-bromoindirubin-3′-acetoxime
Compound 13 (MLS-2384)	6-bromoindirubin-3′-oxime 2-(piperazin-1-yl)ethyl ether
Compound 14	7-bromoindirubin-3′-oxime
Compound 15	7-bromo-5′-carboxyindirubin-3′-oxime
Compound 16	5-fluoroindirubin-3′-oxime 2-(piperazin-1-yl)ethyl ether dihydrochloride
Compound 17	radicicol 6-oxime
Compound 18 (GDC 0879)	2,3-dihydro-5-[1-(2-hydroxyethyl)-3-(4-pyridinyl)-1H-pyrazol-4-yl]-1H-inden-1-one oxime
Compound 19 (SB 590885)	5-[2-[4-[2-(dimethylamino)ethoxy]phenyl]-5-(4-pyridinyl)-1H-imidazol-4-yl]-2,3-dihydro-1H-inden-1-one oxime
Compound 20 (YM-359445)	(3Z)-3-[6-[(4-methylpiperazin-1-yl)methyl]quinolin-2(1H)-ylidene]-2-oxoindoline-6-carbaldehyde O-(1,3-thiazol-4-ylmethyl)oxime.
Compound 21 (JNJ-28871063)	5E-4-amino-6-(4-benzyloxy-3-chlorophenylamino)pyrimidine-5-carboxaldehyde N-(2-morpholin-4-ylethyl) oxime
Compound 22 (JNJ-38158471)	(E)-1-(4-((6-amino-5-((methoxyimino)methyl)pyrimidin-4-yl)oxy)-2-chlorophenyl)-3-ethylurea
Compound 23	1H-indene-1,2,3-trione-2-(phenylhydrazone) 1-oxime
Compound 24	(E)-3-(4-fluorophenyl)-1-phenyl-1H-pyrazole-4-carbaldehyde O-(2-fluorobenzyl) oxime
Compound 25	2,2′-((9-(hydroxyimino)-9H-fluorene-2,7-diyl)bis(oxy))diacetic acid
Compound 26	((E)-2-(2-(3,4-dichlorophenyl)-2-(hydroxyimino)ethyl)chromeno[4,3-c]pyrazol-4(2H)-one)
Compound 27	(E)-1-(13-isobutyl-4-methyl-6-methylene-2,4,6,7,8,13-hexahydro-1H-indazolo[5,4-a]pyrrolo[3,4-c]carbazol-10-yl)ethan-1-one O-methyl oxime
Compound 28	2,7-bis(allyloxy)-9H-fluoren-9-one oxime
Compound 29 (4-AN)	phenylcyanomethylenequinone oxime-4-(hydroxyimino) cyclohexa-2,5-dien-1-ylidene](phenyl)ethanenitrile
Compound 30 (IQ-1)	11H-indeno[1,2-b]quinoxalin-11-one oxime
Compound 31	tryptanthrin-6-oxime
Compound 32	(E)-4-(N-(2-(1-(hydroxyimino)ethyl)phenyl)sulfamoyl)phenyl pivalate
Compound 34 (NS 102)	6,7,8,9-tetrahydro-5-nitro-1H-benz[g]indole-2,3-dione 3-oxime
Compound 35 (SZV-1287)	3-(4,5-diphenyl-1,3-oxazol-2-yl)propanal oxime
Compound 36 (AP 18)	4-(4-chlorophenyl)-3-methyl-3-buten-2-one oxime
Compound 37 (A 967079)	(1E,3E)-1-(4-fluorophenyl)-2-methyl-1-pentene-3-one oxime
Compound 38 (NS 383)	8-ethyl-6,7,8,9-tetrahydro-5-phenyl-1H-pyrrolo[3,2-h]isoquinoline-2,3-dione-3-oxime
fMLF	formyl-l-methionyl-l-leucyl-l-phenylalanine
MPTP	1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine
TPA	12-O-tetradecanoylphorbol-13-acetate