Table 1.
Toxicity evaluation of 1-Fe treatment in WT and mSod1 larvae.
| Material | Concentration | Survival % (I treatment; t = 0) | Survival % (I treatment; t = 24 h) | Survival % (II treatment; t = 72 h) | Toxicity | ||||
|---|---|---|---|---|---|---|---|---|---|
| WT | mSod1 | WT | mSod1 | WT | mSod1 | WT | mSod1 | ||
| 1-Fe | 100 μM | 100 | 100 | 0 | 0 | 0 | 0 | death | death |
| 10 μM | 100 | 100 | 100 | 100 | 40 | 45 | decreased heart rate, severe behavioral toxicity with significantly slower and weaker movements and death | decreased heart rate, severe behavioral toxicity with significantly slower and weaker movements and death | |
| 5 μM | 100 | 100 | 100 | 100 | 100 | 100 | mild behavioral toxicity | no obvious drug induced effects | |
| 1 μM | 100 | 100 | 100 | 100 | 100 | 100 | no obvious drug induced effects | no obvious drug induced effects | |
| 0.05 μM | 100 | 100 | 100 | 100 | 100 | 100 | no obvious drug induced effects | no obvious drug induced effects | |