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ZFAND5 directly activates purified 26S proteasomes and increases their ability to hydrolyze peptides and ubiquitin conjugates. (Left Panel) ZFAND5 stimulates the peptidase activity of 26S proteasomes. This activation is dependent on ZFAND5’s C-terminal AN1 domain. (Right Panel) ZFAND5 enhances also degradation of ubiquitinated 32P-dehydrofolate reductase. Its A20 domain is essential for the increased degradation of ubiquitinated proteins.
