Table 4. Blood pressure and main laboratory parameters at different time points after randomization in the 2 study arms.
| Months after transplant | 1 | 6 | 12 | 18 | 24 | 30 | 36 |
|---|---|---|---|---|---|---|---|
| AZA | |||||||
| 24-hour blood pressure | |||||||
| Systolic, mm Hg | 134.9 ± 16.8 | 138.4 ± 15.0** | 139.9 ± 16.5** | 135.0 ± 17.2 | 134.1 ± 15.9 | 136.5 ± 17.4 | 135.3 ± 15.3 |
| Diastolic, mm Hg | 79.3 ± 10.2 | 83.4 ± 9.9** | 82.8 ± 10.0** | 78.5 ± 10.5 | 81.3 ± 8.3* | 78.3 ± 8.8 | 80.3 ± 9.2 |
| Lipids | |||||||
| Total cholesterol, mg/dL | 224.3 ± 49.5 | 219.5 ± 46.9 | 214.5 ± 46.4 | 211.8 ± 45.2 | 215.5 ± 44.6 | 200.6 ± 48.4 | 213.8 ± 42.4 |
| LDL cholesterol, mg/dL | 129.8 ± 33.2 | 136.1 ± 36.0 | 132.8 ± 37.1 | 130.3 ± 31.5 | 136.2 ± 35.0 | 118.3 ± 36.2 | 127.8 ± 33.5 |
| HDL cholesterol, mg/dL | 40.6 ± 14.6 | 47.6 ± 12.9** | 47.1 ± 14.3** | 49.4 ± 15.6** | 47.8 ± 13.1** | 51.7 ± 14.3** | 53.0 ± 18.6** |
| Triglycerides, mg/dL | 220.8 ± 101.0 | 167.4 ± 94.4** | 152.7 ± 78.8** | 147.3 ± 55.0** | 148.5 ± 77.2** | 152.7 ± 94.6** | 146.5 ± 73.5** |
| Kidney function | |||||||
| S. Creatinine, mg/dL | 2.0 ± 1.3 | 1.7 ± 0.7 | 1.6 ± 0.8 | 1.5 ± 0.5** | 1.5 ± 0.6* | 1.6 ± 0.6 | 1.5 ± 0.5* |
| Estimated GFR, mL/min/1.73m2 | 42.1 [30.5; 53.8] | 46.5 [36.6; 57.8]** | 46.4 [39.6; 59.8]** | 48.4 [38.8; 60.5]** | 49.0 [38.6; 63.4]** | 48.4 [39.9; 57.9]** | 49.8 [36.8; 62.5]** |
| Proteinuria, g/24 hours | 0.23 [0.14; 0.46] | 0.19 [0.11; 0.35] | 0.19 [0.12; 0.40] | - | 0.16 [0.10; 0.38] | 0.19 [0.14; 0.42] | 0.16 [0.10; 0.28] |
| Albuminuria, μg/minute | - | 15.0 [8.0; 34.0] | 17.0 [6.0; 43.0] | - | 16.5 [7.0; 59.0] | - | 14.0 [5.0; 36.0] |
| MMF | |||||||
| 24-hour blood pressure | |||||||
| Systolic, mm Hg | 131.1 ± 17.8 | 138.1 ± 15.8** | 136.8 ± 17.9** | 129.7 ± 15.8 | 135.6 ± 14.6* | 134.4 ± 16.5 | 135.5 ± 16.1* |
| Diastolic, mm Hg | 77.3 ± 11.2 | 81.3 ± 10.6** | 80.8 ± 9.3** | 76.4 ± 9.8 | 80.2 ± 7.6** | 78.9 ± 9.3 | 80.1 ± 9.4* |
| Lipids | |||||||
| Total cholesterol, mg/dL | 226.5 ± 52.0 | 215.1 ± 47.1 | 215.0 ± 52.3 | 211.4 ± 51.3 | 208.1 ± 42.8** | 208.8 ± 40.9** | 208.5 ± 40.9** |
| LDL cholesterol, mg/dL | 143.6 ± 42.3 | 134.6 ± 37.8* | 135.2 ± 42.5 | 124.7 ± 39.6* | 129.5 ± 31.6 | 125.2 ± 29.1* | 128.2 ± 35.0 |
| HDL cholesterol, mg/dL | 42.1 ± 14.5 | 45.3 ± 13.4** | 46.2 ± 14.1** | 50.4 ± 15.2** | 49.1 ± 16.1** | 53.2 ± 15.5** | 53.2 ± 17.0** |
| Triglycerides, mg/dL | 221.1 ± 93.6 | 166.1 ± 77.8** | 152.2 ± 82.7** | 164.6 ± 72.9** | 146.5 ± 75.0** | 145.7 ± 76.7** | 147.3 ± 83.3** |
| Kidney function | |||||||
| S. Creatinine, mg/dL | 1.76 ± 1.0 | 1.56 ± 0.6* | 1.47 ± 0.5** | 1.58 ± 0.6 | 1.49 ± 0.5* | 1.59 ± 0.9 | 1.46 ± 0.6** |
| Estimated GFR, mL/min/1.73m2 | 45.9 [35.5; 54.6] | 47.8 [38.3; 62.6]** | 51.6 [40.6; 64.2]** | 47.9 [37.6; 62.6]** | 50.7 [39.9; 65.5]** | 51.5 [40.4; 63.2]** | 53.8 [40.6; 65.7]** |
| Proteinuria, g/24 hours | 0.20 [0.12; 0.39] | 0.19 [0.12; 0.30] | 0.18 [0.09; 0.28] | - | 0.15 [0.10; 0.27] | 0.20 [0.12; 0.26] | 0.15 [0.11; 0.29] |
| Albuminuria, μg/minute | - | 20.0 [8.0; 68.0] | 16.0 [7.0; 55.0] | - | 19.0 [8.0; 57.0] | - | 20.5 [7.0; 61.5] |
Data are means ± SD or median [IQR]. t Test or signed rank:
*p < 0.05,
**p < 0.01 vs month 1. All between-group comparisons statistically not significant by ANCOVA. GFR was estimated based on MDRD formula.
ANCOVA, analysis of covariance; AZA, azathioprine; GFR, glomerular filtration rate; IQR, interquartile range; MMF, mycophenolate mofetil; SD, standard deviation.