Fig 2. Co-occurrence of rare non-synonymous variants in genes associated with CZS phenotypes.

Comut plot representation of harmful genetic variants in a series of 22 newborns with CZS. (Right) Frequency of variants per patient ranked by the number of mutations. (Middle) Heat-map of variants in each patient for an individual gene by the type of mutation. (Bottom) Human Phenotype Ontology term associated with each gene. Asterisk indicates genes with likely pathogenicity variants.