. 2021 Jun 24;16(6):e0252711. doi: 10.1371/journal.pone.0252711

Table 1. Morphometric data of the GK and Wistar rats at early and late timepoints.

	Early		Late
	Wistar n = 6	GK n = 4	Wistar n = 6	GK n = 7
HbA1C (%)	4.77 ± 0.15	6.68 ± 0.88^***	4.62 ± 0.34^ϕϕϕ	9.36± 0.73^****,^####,^ϕϕϕϕ
Body Weight (BW; g)	681.00 ± 32.44	449.75± 18.64^****	951.83± 104.68^****,^ϕϕϕϕ	392.57± 12.18^****,^####
Tibia Length (mm)	42.17 ± 0.75	38.13 ± 0.85^****	45.67± 0.52^****,^ϕϕϕϕ	40.64± 0.63^***,^ϕϕϕϕ,^####
Heart weight (HW): BW (mg/g)	2.20 ± 0.13	2.70 ± 0.15^**	1.91 ± 0.22^*,^ϕϕϕϕ	2.94 ± 0.16^#,^ϕϕ
Lung weight (LW): BW (mg/g)	3.11 ± 0.33	3.18 ± 0.18	2.38 ± 0.36^*,^ϕϕ	3.40 ± 0.21^##
Left Kidney weight (KW): BW (mg/g)	2.41 ± 0.23	3.12 ± 0.31^*	2.26 ± 0.52^ϕϕ	5.10± 0.35^****,^ϕϕϕϕ,^###

HbA1C (%) Hemoglobin A1C, Body Beight (BW/g), Tibal length (TL/mm), heart weight/body weight ratio (mg/g), lung weight/body weight ratio (mg/g), LKW/BW left kidney weight/body weight (mg/g) ratio. Where early = 28 weeks Late = 48 weeks GK = Goto Kakizaki rats, Wistar = Wistar rats.

* = p<0.05, ** = p<0.01, *** = p<0.001 and **** = p<0.0001 when compared to early Wistar;

^# = p<0.05, ^## = p<0.01, ^### = p<0.001 and ^#### = p<0.0001 when compared to late Wistar;

^ϕ = p<0.05, ^ϕϕ = p<0.01, ^ϕϕϕ = p<0.001 and ^ϕϕϕϕ = p<0.0001 when compared to early GK;

A Two-Way ANOVA with multiple comparisons Holm-Sidak test was used to compare groups across different time points. Data is expressed as mean±SEM N = 4–8 per group.