Fig 4. Comparisons of efficacy and discontinuation rates of all selective serotonin reuptake inhibitors and serotonin and norepinephrine reuptake inhibitors, considering 3-level multiple meta-regression models.

Comparisons between treatments should be read from left to right, and the estimate is in the cell in common between the column-defining treatment and the row-defining treatment. For efficacy, standardized mean differences (SMDs) below 0 favor the column-defining treatment. For safety, odds ratio (ORs) above 1 favor the column-defining treatment.