Table 1. Repeatability and accuracy evaluation of SensiScreen® EGFR Liquid assays: Number of copies mutated for Exon 19 deletion, T790M or L858R.
Template | Number of mutated copies detected | Total | ||||
---|---|---|---|---|---|---|
0 | 1 | 2 | ≥3 | |||
Exon 19 deletion | c.2235-2249del (Glu746-Ala750del) | 25 | 77 | 102 | ||
T790M | c.2369C>T (p.T790M) | 20 | 82 | 102 | ||
L858R | c.2573T>G (p.L858R) | 23 | 79 | 102 | ||
Poisson (λ = 1) | NA | 37.5 | 64.5 | 102 | ||
37.5 | 18.8 | 8.2 | ||||
Poisson (λ = 1.5) | NA | 22.8 | 79.2 | 102 | ||
34.1 | 25.6 | 19.5 |
Abbreviations: EGFR, Epidermal growth factor receptor; NA, not available.