Table 5. Statistics of mutations in the S protein of the 13 PEDV strains in comparison with ZJ08.

Domain	Mutations	Domain	Mutations	Domain	Mutations
SP	2TP3→2KS3		231S→231I/L		763L→763S
	5I→5T/N		241DS242→241EP/L242		765D→765S
	15L→15S	S1-CTD	265L/265V		773M→773T
S1-NTD	27QSTI30→27S/AANT30		281W→281L		778I→783M/I
	ΔΔ→55T/IG56		283I→283M	S2	801S→801S/T
	56MNS58→56GEN58		298MM299→298TI299		805V→805A
	ΔΔΔΔ→59QGVN62		308A→308V		853E→853E/D
	60S→60T		323F→323S		890G→890R
	62Y→66H/Y		330S→330S/A		958A→958V
	64GTGIE68→64AGQHP68		335T→335T/A		962L→962F
	80Y→80H		341L→341F/L		964T→964S
	82DS83→82RG83		353K→353S/L		972H→972Y
	85Q→85H		355I→355I/T		994L→994M/L
	114S→114N		362TI363→362AL/I363		1027N→1027K
	116I→116T		362V→362A		1043S→1043A
	126DN127→126NI127		364E→364Q		1050I→1050V
	134V→134A		373V→373L/V		1095A→1095A/S
	135N→135N/D		377K→377N		1112Q→1112Q/L
	Δ136N		392K→392R		1139E→1134E/D
			429D→434G/D		1141I→1141I/V
	Δ153H		437V→442I		1161N→1161N/D
	154LQDGK158→154MSEHS158		473S→473A		1166D→1166A
	159NI160→159ΔΔ160		495I→495I/T		1172GD1173→1172DE1173
	173A→173S		516A→521S/A		1192TY1193→1192NH1193
	181I→181F		Δ551L		1231S→1231R
	191R→191K		600G→600S		1259I→1259T
	195KRS197→195SGG197		608G→613V/G		1261P→1261S/P
	205T→210E		632Q→632E	TM	1275L→1275L/T
	222Y→222S	S1 other domain	718N→718N/S	Cyto	1297R→1297Q
	224E→224Q		723N→723S		1358G→1358C/G
					1375A→1375V