Table 1. Dissociation constants (K_d, nM) of the compounds for 12 human CA isoforms.

No	CA I	CA II	CA III	CA IV	CA VA	CA VB	CA VI	CA VII	CA IX	CA XII	CA XIII	CA XIV
1.	270	560; 1125[10]	>200000	1200	320	470	2600	400	860	420	570	430
2.	480; 1200 [22]	3.2; 38 [22]	550; 680000[22]	6.3; 15000[22]	25; 630[22]	0.25; 21[22]	15; 79[22]	0.46; 26[22]	3.1; 50[22]	3.4; 50[22]	4.5; 23m[22]	0.92; 345[22]
3.	23000	370; 372 [23]	15000	310	830	48	620	70	130	180	39	250
4.	23000; 328[22]	2600; 7190 [23] 290[22]	200000; 790000[22]	1600; 427[22]	2000; 4225[22]	200; 603[22]	830; 3655[22]	870; 5010[22]	350; 367[22]	570; 355[22]	530; 3885m[22]	620; 4105[22]
5.	6200; 345 [24]	1700; 2600[23]; 91 [24]	>200000; 560000 [24]	1000; 449 [24]	3300; 763 [24]	1500; 134 [24]	1500; 2459 [24]	710; 7.9 [24]	260; 87 [24]	420; 312 [24]	940; 645m [24]	590; 3450 [24]
6.	940	1200	270000	270	1100	140	430	500	150	170	430	360
7.	250	500	>200000	330	5000	280	580	100	100	1600	190	230
8.	4300	6.4; 16.7 [23]	4500	43	90	6.6	500	15	26	18	0.64	36
9.	1600	790	51000	330	1500	61	490	250	120	120	150	51
10.	50000; 2840 [22]	17000; 435 [22]	>200000; 870000 [22]	24000; 4780 [22]	40000; 10200 [22]	910; 429 [22]	29000; 8250 [22]	17000; 433 [22]	1600; 412 [22]	31000; 305 [22]	470; 15400m [22]	3600; 360 [22]
11.	5800	1700	>200000	1600	32000	360	5300	440	210	480	910	130
12.	2800; 51900 [24]	130; 1420 [23] 2520 [24]	11000; 230000 [24]	47; 213 [24]	280; 890 [24]	13; 274 [24]	130; 1606 [24]	42; 0.23 [24]	140; 36 [24]	150; 10 [24]	41; 13m [24]	88; 4950 [24]
13.	4900	370; 14600[23]	>200000	360	440	660	470	250	330	760	170	200
14.	56000	10000	>200000	1400	>200000	61000	36000	93000	15000	26000	680	15000
15.	830; 62 [24]	630; 3140 [23] 65 [24]	>200000; 3200000 [24]	920; 564 [24]	>200000; 499 [24]	120000; 322 [24]	49000; 245 [24]	620; 513 [24]	200; 420 [24]	120; 261 [24]	230; 550m [24]	420; 52 [24]
16.	310; 348 [24]	35; 11.9 [23]; 138 [24]	17000; 11000 [24]	16; 196 [24]	4800; 917 [24]	470; 9 [24]	110; 1347[24]	43; 2.8 [24]	33; 23 [24]	12; 4.5 [24]	30; 15m [24]	19; 4130[24]
17.	1600	76	>200000	250	42000	500	420	100	42	89	51	58
18.	51000; 35000 [22]	14000; 1260 [22]	180000	2100	7100	15000	3900	36000	2300	20000	1100	4700
19.	13000	15000	>200000	4400	11000	19000	5300	27000	2700	28000	930	5700
20.	130000; 54000 [22]	2800; 2000 [22]	>200000; 610000 [22]	91; 216 [22]	5800; 750 [22]	1400; 312 [22]	990; 1714 [22]	8300; 2.1 [22]	800; 320 [22]	15000; 5.4 [22]	180; 15m [22]	1300; 5432 [22]

The K_d values in the top rows were determined in this study by FTSA and are the averages of at least two measurements. The second and the following rows in the cell (if provided) show the literature values of inhibition constants of CA enzymatic activity, K_i (nM), or the dissociation constants K_d (nM) (listed together with the citation).

^m murine protein.