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. Author manuscript; available in PMC: 2021 Jun 24.
Published in final edited form as: J Med Chem. 2020 Feb 17;63(5):2511–2526. doi: 10.1021/acs.jmedchem.9b01440

Figure 4.

Figure 4.

Effect of compound 10b on liver histopathologic and biochemical phenotypes in the STAM mouse model. Representative images of Hematoxylin and Eosin staining and Sirius Red staining in liver sections (A), Sirius Red staining quantified as a measure of fibrosis (B). NAFLD Activity Score (C) is the sum of individual parameters: steatosis (D), inflammation (E), and ballooning (F). Graphs show mean ± SEM. * indicates p < 0.05, by Kruskal-Wallis test with Dunn’s correction for multiple comparisons for non-parametric data. n=8 male mice per group.