Skip to main content
. Author manuscript; available in PMC: 2021 Jun 24.
Published in final edited form as: J Med Chem. 2020 Feb 17;63(5):2511–2526. doi: 10.1021/acs.jmedchem.9b01440

Table 4.

Oxygen consumption rates (OCR) of unsymmetrical derivatives in L6 rat myoblast cells.

graphic file with name nihms-1710438-t0072.jpg
Entry R % of BAM15 OCRa EC50, μM Entry R % of BAM15 OCRa EC50, μM
10aa graphic file with name nihms-1710438-t0073.jpg NA -- 10ad graphic file with name nihms-1710438-t0074.jpg 46%b >100
10ab graphic file with name nihms-1710438-t0075.jpg NA -- 10ae graphic file with name nihms-1710438-t0076.jpg 54%b 13.4 ± 3.2
10ac graphic file with name nihms-1710438-t0077.jpg NA -- 10af graphic file with name nihms-1710438-t0078.jpg NA --
a

Integrated area under OCR dose curve above baseline relative to that of BAM15 expressed as percent. NA = No Activity.

b

Highest tested concentration is 200 μM. BAM15 was tested up to 200 μM.