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Online SEC-nMS analysis of initial (T0), intermediate (T1 and T2) and end (T-GlyCLICK-DM1) conjugation products. (A) Zoom on SEC-UV chromatograms at 280 nm; I = HMW dimers, II = main product, III = Fc-Fab fragments and IV = LC, Fd and Fab fragments. (B) Zoom on SEC-nMS spectra obtained for the different main products; ● = a-fucosylation (−146 Da), ✱ = glycation (+162 Da).
