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Online SEC-nMS analysis of thermally-stressed T-GlyCLICK-DM1. (A) Overlaid SEC chromatograms of stressed (solid line) and non-stressed (dotted line) samples. Relative amounts of HMWS and LMWS are given for the stressed sample; I = HMW dimers, II = main product, III = Fc-Fab fragments and IV = LC, Fd and Fab fragments. (B) SEC-nMS spectra of species generated upon thermal stress. ⬨ = sulfurized Cys214 (+32 Da compared to LC Asp1-Cys214).
