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. 2021 May 24;10(6):626. doi: 10.3390/antibiotics10060626

Table 2.

Minimum Inhibitory Concentration of 17 phenalenone derivatives tested against 6 bacterial strains (E.c. 1: Escherichia coli CIP54.8T, E.c. 2: Escherichia coli CIP53.126, S.a.: Staphylococcus aureus CIP76.25, S.e.: Staphylococcus epidermidis CIP109.562, B.c.: Bacillus cereus CH, P.a.: Pseudomonas aeruginosa CIP76.110) under dark (D) and light (L) conditions.

Compound Minimum Inhibitory Concentration (µM)
E.c. 1 E.c. 2 P.a. S.a. S.e. B.c.
D L D L D L D L D L D L
4a >200 100 >200 100 >200 200 >200 100 >200 200 >200 200
4b >200 >200 >200 100 200 200 100 12.5 100 12.5 100 50
5 >200 >200 >200 >200 >200 >200 >200 100 >200 >200 >200 >200
5a >200 >200 >200 >200 >200 >200 >200 >200 >200 200 >200 >200
5b * >200 >200 >200 >200 >200 200 >200 200 >200 200 >200 200
6a >200 50 >200 25 >200 200 50 6.25 200 12.5 >200 100
6b ND ND ND ND ND ND 25 3.12 6.25 0.78 25 6.25
7a >200 200 >200 100 >200 >200 50 6.25 25 6.25 100 50
7b >200 >200 >200 >200 >200 >200 6.25 0.78 6.25 0.78 12.5 3.12
8a >200 100 >200 50 >200 100 25 0.78 12.5 1.56 25 12.5
8b >200 200 >200 100 >200 200 50 0.39 12.5 0.78 50 6.25
9a >200 100 >200 50 >200 >200 >200 25 >200 12.5 >200 200
9b >200 >200 >200 >200 25 25 6.25 1.56 12.5 1.56 6.25 6.25
10 >200 100 >200 50 >200 12.5 >200 50 >200 100 >200 >200
10a >200 >200 >200 >200 >200 200 >200 200 >200 100 >200 >200
10b >200 >200 >200 >200 >200 >200 100 50 >200 12.5 >200 >200
SAPyR >200 200 >200 >200 >200 50 >200 50 200 25 >200 50

* Compound obtained with a purity of 70%, mixed with 30% of compound 5. ND: Not data, compounds not soluble at the concentrations.