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. 2021 May 24;11(6):1522. doi: 10.3390/ani11061522

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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PM-sEVs circ-XPO4 regulates the miR-221-5p/pIgR pathway in IPEC-J2 cells. (A) Dual luciferase reporter system detect the targeting relationship between miR-221-5p and circ-XPO4 (n = 8). (B–D) qRT-PCR analysis of circ-XPO4, miR-221-5p, and pIgR expression levels in IPEC-J2 cell treated with PM-sEVs + si.NC or PM-sEVs + si.circ-XPO4 (n = 6). (E,F) Western Blotting analysis of pIgR protein levels in IPEC-J2 cell treated with PM-sEVs + si.NC or PM-sEVs + si.circ-XPO4 (n = 4). * p < 0.05; ** p < 0.01.